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Eliquis And Xarelto: A Comparison Of Two Anticoagulants In 2023

Eliquis vs Xarelto Main Differences and Similarities


When it comes to preventing blood clots and reducing the risk of stroke, two popular medications that often come up in discussions are Eliquis and Xarelto. As we delve into the year 2023, it is crucial to understand the differences and similarities between these two anticoagulants to make informed decisions about their usage.

The Mechanism of Action

Eliquis and Xarelto both belong to a class of medications called direct oral anticoagulants (DOACs). These drugs work by inhibiting specific clotting factors in the blood, thereby preventing the formation of blood clots. Eliquis primarily targets factor Xa, while Xarelto also inhibits factor Xa but to a lesser extent.

Efficacy and Safety

Both Eliquis and Xarelto have been extensively studied in clinical trials and have shown efficacy in reducing the risk of stroke in patients with atrial fibrillation and in preventing blood clots after orthopedic surgery. However, individual responses to these medications may vary, and it is essential to consult a healthcare professional to determine the most suitable option for each individual.


Eliquis has gained popularity due to its effectiveness in preventing strokes and reducing the risk of blood clots. It has shown superiority over warfarin in clinical trials, with a lower risk of bleeding and a more predictable response. Eliquis also requires fewer dietary restrictions and less frequent monitoring compared to warfarin.


Xarelto is another widely prescribed anticoagulant that has proven efficacy in preventing blood clots. It has been shown to be non-inferior to warfarin in various studies. Xarelto offers the convenience of once-daily dosing and has a lower risk of major bleeding compared to warfarin.

Factors to Consider

When choosing between Eliquis and Xarelto, several factors need to be taken into account:

1. Indication

The specific medical condition being treated, such as atrial fibrillation or deep vein thrombosis, can influence the choice between Eliquis and Xarelto. It is crucial to follow the prescribing healthcare professional’s recommendations based on the individual’s medical history and condition.

2. Drug Interactions

Both Eliquis and Xarelto can interact with certain medications, including over-the-counter drugs, herbal remedies, and prescription medications. It is essential to inform the healthcare professional about all medications being taken to avoid potential interactions.

3. Renal Function

Renal function plays a significant role in determining the appropriate dosage of Eliquis and Xarelto. People with impaired kidney function may require adjusted doses to minimize the risk of bleeding.

4. Cost

Cost is another factor to consider when comparing Eliquis and Xarelto. The prices of these medications may vary depending on factors such as insurance coverage and geographical location. It is advisable to explore different options and consult with the healthcare professional to find the most affordable choice.

Potential Side Effects

As with any medication, both Eliquis and Xarelto carry potential side effects. The most common side effect of these anticoagulants is bleeding. However, serious bleeding events are relatively rare and can be managed with appropriate medical intervention. Other side effects may include gastrointestinal discomfort, easy bruising, and headache.


In conclusion, Eliquis and Xarelto are two effective anticoagulant medications that have revolutionized the prevention of blood clots and strokes. While both medications offer benefits and have similar efficacy, individual factors and preferences may influence the choice between the two. It is crucial to consult with a healthcare professional to determine the most appropriate anticoagulant for each individual’s specific needs.

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